TAL1

Proteína 1 de leucemia linfoide aguda de células T
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 2YPA , 2YPB
Identificadores
Símbolos	TAL1 (HGNC: 11556) SCL, TCL5, tal-1
Identificadores; externos	OMIM: 187040 ; MGI: 98480 ; HomoloGene: 2400 ; EBI: TAL1; GeneCards: Gen TAL1; UniProt: TAL1;
Locus	Cr. 1 p33
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
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	Más información
Ortólogos
Humano	Ratón
6886	21349
Véase HS	Véase MM
P17542	P22091
NM_003189	NM_011527
NP_003180	NP_035657
Cr. 1:; 47.68 – 47.7 Mb	Cr. 4:; 115.06 – 115.07 Mb
[1] ;	[2]
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El factor de transcripción TAL bHLH 1, factor de diferenciación eritroide (proteína 1 de leucemia linfoide aguda de células T) es una proteína codificada en humanos por el gen tal1.^[1]^[2] TAL1 es un factor de transcripción con un dominio hélice-bucle-hélice implicada, cuando está truncada o ausente, en el desarrollo de leucemia linfoide aguda de células T.

Sinónimos

SCL, TCL5, tal-1, bHLHa17

Interacciones

La proteína TAL1 ha demostrado ser capaz de interaccionar con:

Referencias

↑ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (Aug de 1989). «Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma». Proc Natl Acad Sci U S A 86 (13): 5039-43. PMC 297552. PMID 2740341.
↑ «Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1».
↑ ^3,0 ^3,1 Valge-Archer, V E; Osada H, Warren A J, Forster A, Li J, Baer R, Rabbitts T H (Aug. de 1994). «The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (18): 8617-21. ISSN 0027-8424. PMID 8078932.
↑ ^4,0 ^4,1 Wadman, I; Li J, Bash R O, Forster A, Osada H, Rabbitts T H, Baer R (Oct. de 1994). «Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia». EMBO J. (ENGLAND) 13 (20): 4831-9. ISSN 0261-4189. PMID 7957052.
↑ ^5,0 ^5,1 ^5,2 ^5,3 ^5,4 Goardon, Nicolas; Lambert Julie A, Rodriguez Patrick, Nissaire Philippe, Herblot Sabine, Thibault Pierre, Dumenil Dominique, Strouboulis John, Romeo Paul-Henri, Hoang Trang (Jan. de 2006). «ETO2 coordinates cellular proliferation and differentiation during erythropoiesis». EMBO J. (England) 25 (2): 357-66. ISSN 0261-4189. PMID 16407974. doi:10.1038/sj.emboj.7600934.
↑ Huang, S; Brandt S J (Mar. de 2000). «mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor». Mol. Cell. Biol. (UNITED STATES) 20 (6): 2248-59. ISSN 0270-7306. PMID 10688671.
↑ ^7,0 ^7,1 Osada, H; Grutz G, Axelson H, Forster A, Rabbitts T H (Oct. de 1995). «Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (21): 9585-9. ISSN 0027-8424. PMID 7568177.
↑ Lécuyer, Eric; Herblot Sabine, Saint-Denis Marianne, Martin Richard, Begley C Glenn, Porcher Catherine, Orkin Stuart H, Hoang Trang (Oct. de 2002). «The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1». Blood (United States) 100 (7): 2430-40. ISSN 0006-4971. PMID 12239153. doi:10.1182/blood-2002-02-0568.
↑ Hsu, H L; Wadman I; Baer R (Apr. de 1994). «Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (8): 3181-5. ISSN 0027-8424. PMID 8159721.
↑ Huang, S; Qiu Y, Stein R W, Brandt S J (Sep. de 1999). «p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein». Oncogene (ENGLAND) 18 (35): 4958-67. ISSN 0950-9232. PMID 10490830. doi:10.1038/sj.onc.1202889.

Enlaces externos

En HomoloGene: TAL1

En Genome:TAL1
En MalaCards.Enfermedades que coinciden con:TAL1
En Estudio de asociación del genoma completo (GWAS) TAL1

[pmid2740341-1] Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (Aug de 1989). «Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma». Proc Natl Acad Sci U S A 86 (13): 5039-43. PMC 297552. PMID 2740341.

[entrez-2] «Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1».

[pmid8078932-3] 3,0 ^3,1 Valge-Archer, V E; Osada H, Warren A J, Forster A, Li J, Baer R, Rabbitts T H (Aug. de 1994). «The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (18): 8617-21. ISSN 0027-8424. PMID 8078932.

[pmid7957052-4] 4,0 ^4,1 Wadman, I; Li J, Bash R O, Forster A, Osada H, Rabbitts T H, Baer R (Oct. de 1994). «Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia». EMBO J. (ENGLAND) 13 (20): 4831-9. ISSN 0261-4189. PMID 7957052.

[pmid16407974-5] 5,0 ^5,1 ^5,2 ^5,3 ^5,4 Goardon, Nicolas; Lambert Julie A, Rodriguez Patrick, Nissaire Philippe, Herblot Sabine, Thibault Pierre, Dumenil Dominique, Strouboulis John, Romeo Paul-Henri, Hoang Trang (Jan. de 2006). «ETO2 coordinates cellular proliferation and differentiation during erythropoiesis». EMBO J. (England) 25 (2): 357-66. ISSN 0261-4189. PMID 16407974. doi:10.1038/sj.emboj.7600934.

[pmid10688671-6] Huang, S; Brandt S J (Mar. de 2000). «mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor». Mol. Cell. Biol. (UNITED STATES) 20 (6): 2248-59. ISSN 0270-7306. PMID 10688671.

[pmid7568177-7] 7,0 ^7,1 Osada, H; Grutz G, Axelson H, Forster A, Rabbitts T H (Oct. de 1995). «Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (21): 9585-9. ISSN 0027-8424. PMID 7568177.

[pmid12239153-8] Lécuyer, Eric; Herblot Sabine, Saint-Denis Marianne, Martin Richard, Begley C Glenn, Porcher Catherine, Orkin Stuart H, Hoang Trang (Oct. de 2002). «The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1». Blood (United States) 100 (7): 2430-40. ISSN 0006-4971. PMID 12239153. doi:10.1182/blood-2002-02-0568.

[pmid8159721-9] Hsu, H L; Wadman I; Baer R (Apr. de 1994). «Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (8): 3181-5. ISSN 0027-8424. PMID 8159721.

[pmid10490830-10] Huang, S; Qiu Y, Stein R W, Brandt S J (Sep. de 1999). «p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein». Oncogene (ENGLAND) 18 (35): 4958-67. ISSN 0950-9232. PMID 10490830. doi:10.1038/sj.onc.1202889.

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